Transactions of the Royal Society of Edinburgh . Bache {Op. x. p. 487) to possess cathartic, emetic, and diuretic American Eclectics have used, under the name of iridin or irisin, anoleo-resin prepared in the same way as euonymin (p. 170). The dose of this is1-5 grains as a purgative. It is thought to unite cholagogue and diureticwith aperient properties (Wood and Bache, loc. tit.). An anonymous writerin the Lancet (August 30, 1862) states that it is gentler in its action than VOL. XXIX. PART I. 2 Y 174 PROFESSOR RUTHERFORD ON THE podophyllin, and more reliable when a slight cho
Transactions of the Royal Society of Edinburgh . Bache {Op. x. p. 487) to possess cathartic, emetic, and diuretic American Eclectics have used, under the name of iridin or irisin, anoleo-resin prepared in the same way as euonymin (p. 170). The dose of this is1-5 grains as a purgative. It is thought to unite cholagogue and diureticwith aperient properties (Wood and Bache, loc. tit.). An anonymous writerin the Lancet (August 30, 1862) states that it is gentler in its action than VOL. XXIX. PART I. 2 Y 174 PROFESSOR RUTHERFORD ON THE podophyllin, and more reliable when a slight cholagogue action is required fora lengthened period. This statement, however, has been generally neglected/and the substance appears to be unknown to most persons. The substance employed by us was obtained from Messrs Duncan &Flockhart of Edinburgh. Experiment 29. Dog that had fasted seventeen hours. Weight 227 kilo-grammes (fig. 29).—2 cc. bile and 3 cc. water injected into the duodenum at same with 5 grains of iridin injected at Fig. 29. —Secretion of bile before and after iridin. 2 cc. bile and 3 injected into the duodenum at b. 5 grains iridin in thesame fluid injected at i. Experiment 29. Secretion of bile Secretion of bile per 15. per kilogramme ofdog: per liour. cc. 1-8 11 1-25 1-0 1-15 b 1-5 \ 1-16 1-3 >0-227cc. 1-2 ) i 1-4 1-25 1-45 13 1-55 1-55 2 75 2-45 2-8 \ 4-02-65 > 0-537 cc. 275 ) 2-4 25 2-1 2 4 2-6 2-3 15 1-3 Necropsy.—Stomach normal. Mucous membrane of upper two-thirds ofsmall intestine rather more vascular than usual. This portion of the intestinecontained 63 cc. of fluid, thus affording evidence of a decided purgativeeffect. Experiment 30. Dog that had fasted eighteen hours. Weight kilo-grammes (fig. 30).—2 cc. bile and 2 cc. water injected into the duodenum at same with 5 grains of iridin injected at i. PHYSIOLOGICAL ACTIONS OF DRUGS ON THE SECRETION OF BILE. 175
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