. The American journal of roentgenology, radium therapy and nuclear medicine . Fig. 8. Microphotograph. Shows a Great Deal ofNew Bone Formation in the Vicinity of an OldBridge of Compact Bone Tissue, b shows oldbone; a new bone. the cancer cells and produces a local cure ofthe growth. In other words radium and the .r-rays per- form with greater precision and by fargreater frequency what the organism itselfattempts to do haltingly and in rare Fig. 9. Microphotograph. Two Bone LacunaeFilled with Carcinoma Cells. Low magnifica-tion. A shows bone; B carcinoma. ACTION OF RADIUM ON MALI
. The American journal of roentgenology, radium therapy and nuclear medicine . Fig. 8. Microphotograph. Shows a Great Deal ofNew Bone Formation in the Vicinity of an OldBridge of Compact Bone Tissue, b shows oldbone; a new bone. the cancer cells and produces a local cure ofthe growth. In other words radium and the .r-rays per- form with greater precision and by fargreater frequency what the organism itselfattempts to do haltingly and in rare Fig. 9. Microphotograph. Two Bone LacunaeFilled with Carcinoma Cells. Low magnifica-tion. A shows bone; B carcinoma. ACTION OF RADIUM ON MALIGNANT TUMORSOF THE SKELETON. The mechanism of the action of the rayson malignant tumors, the sequence of eventsas well as the fact that results obtainedthrough this action resemble the phenomenawhich occur spontaneously in the organism,can be demonstrated most clearly in thestudy of the influence which radium exertson carcinoma and sarcoma of the skeleton. In a pathological study of skeletal metas-tases of carcinoma, the writer ^ has shownthat the metastasis usually begins its devel-opment within the marrow, and when thenodule of carcinoma is small, the surround-ing bone-marrow appears quite normal (). As the tumor nodule increases in size, it The Rationale of Radiumtherapy in Cancer 559 approaches and invades the compact osseoustissue or the compact osseous partitions ofthe cancellated bone. Then there begin toappear characteristic changes
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