. The actinomycetes. Actinomycetales. DESCRIPTIONS OF ANTIBIOTICS 173 trace components including Co, Cna, Cia, Csa, Csa , and C4 (36, 37, 87). These components have the following Rcj values (Rf value relative to actinomycin VI(Co)) (87):Cu = ; VICC.) = ; C3a = ; IV(CO = ; C-a = ; C4 = ; Cia = ; VII (Ca) = System: n-Dibutyl ether, n-butanol, and 5 per cent aqueous /3-naph- thalene sulfonic acid. Other components have been reported formed when a "C mixture"-pro- ducing streptomycete was grown in the presence of various amino acids (64) (see actinomycin mi
. The actinomycetes. Actinomycetales. DESCRIPTIONS OF ANTIBIOTICS 173 trace components including Co, Cna, Cia, Csa, Csa , and C4 (36, 37, 87). These components have the following Rcj values (Rf value relative to actinomycin VI(Co)) (87):Cu = ; VICC.) = ; C3a = ; IV(CO = ; C-a = ; C4 = ; Cia = ; VII (Ca) = System: n-Dibutyl ether, n-butanol, and 5 per cent aqueous /3-naph- thalene sulfonic acid. Other components have been reported formed when a "C mixture"-pro- ducing streptomycete was grown in the presence of various amino acids (64) (see actinomycin mixtures E and F). The infrared spectrum of actinomycin IV (Ci) is given in reference 36 and that of actinomycin VII (C3) in reference 37. The other physical and chemical properties of actino- mycins IV (Ci), VKC.), and VII(C3) are given in Table 40. Their amino acid content is given in Table 39 (24, 77). On mild acid hydrolysis, actino- mycin VII(Cs) splits off one molecule of ammonia andformsa "desamino actinomycin" (C64H89O17N11; brick-red rhomboid crystals; 239°C). The chromophore of this degradation product (3 hy- droxy! , 8 dimethylphenoxazone- (2) -dicarboxylic acid-(4,5) (40) is shown below: COOH OH. "AA-AC mixture", contains two actinomycins in major amounts, IV (AA) and VII(AC), and a minor component with an amino acid content like that of VII, but not as yet completely char- acterized (30, 33, 83). References giving data concerning the "mixtures" include 16, 29, 36, 37, 40 ("C mixture"); and 14, 30, and 33 ("AA-AC mixture"). Biological activity: The minimal inhibitory con- centrations of some of the component actinomycins of the "C mixture" against/^, suhtilisare as follows (in ;ug per ml): actinomycin IV (Ci), ; VI (C.), ; VII (C3), ; C«, 19; Cja, 50; and C3, 28. The activity against mammary carcinoma TM 8013 and lymphosarcoma T 24 179 of the "C mix- ture" is accounted for by actino
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