. The Journal of laboratory and clinical medicine . cific aiiapliylactogen largely within or without the cells, and with theformation of diffusible irritants capable of producing acute hyperemia, edemaand leukocytic infiltration of the skin. The fact remains that from our observations the evidence is fairly con-clusive that there exists in these individuals a susceptibility to hexamethyl-enamina which could not be demonstrated in the controls. Furthermore, withthe evidence already at hand that it was not possible to produce hematuriain unsusceptible individuals, taking the hyperacid urine as a
. The Journal of laboratory and clinical medicine . cific aiiapliylactogen largely within or without the cells, and with theformation of diffusible irritants capable of producing acute hyperemia, edemaand leukocytic infiltration of the skin. The fact remains that from our observations the evidence is fairly con-clusive that there exists in these individuals a susceptibility to hexamethyl-enamina which could not be demonstrated in the controls. Furthermore, withthe evidence already at hand that it was not possible to produce hematuriain unsusceptible individuals, taking the hyperacid urine as a necessary factorin the elaboration of the irritant formaldehyde as the contributing cause, wehave come to the conclusion that the evidence is sufficient to warrant thestatement that individual hypersensitivity or an allergy to hexamethylenaminais the etiologic factor in the production of these hematurias. The source of the blood in hematuria caused by the administration ofhexamethvlenamina lias been more or less indefinite. The prevailing opinion. Fig. 1.—Showing- local reaction from various drugs inoculated into skin abrasions on forearm inthe following dilutions: hexamethylenamina 1:5, 1:10, 1:50, 1:100; cafleine citrate 1:10; salicylic acid1:10; quinine chlorhydrosulphate 1:20; adrenalin 1:1000; normal saline (); formalin 1:50. seems to be that it comes from the bladder and that the kidneys remainunaffected. The evidence obtained in the above five cases of hematuria points fairlydefinitely to the bladder as the site of the hemorrhage. The presence of anacute hemorrhagic nephritis which would be necessary to cause such a markedhematuria of renal origin, could be ruled out by the absence of constitutionalsymptoms, the absence of casts, especially blood easts, in the urine, therapid subsidence of the symptoms and the complete recovery of the patientin a few days with no sequalae. The symptoms in these patients pointeddirectly to the bladder as evidenced by the tenesmus,
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