. The actinomycetes. Actinomycetales. DEyCRIPTlONS OF ANTIBIOTICS 313 4. Sato, K. and Katagiri, K. Cheinothera})y 5: 182-183. 1957. 5. Miyakawa, T. et al. Japan. J. Microbiol. 2: 53-62, 1958. 6. Hinuma, Y. et al. Jajjan. J. MicTot)iol. 2: 63-68, 1958. 7. Hinuma, Y. et al. Japan. J. Microhiol. 2: 117-125, 1958. 8. An>^ai, O. Vims (Osaka) »: 174-181, 1958. jNarboniyciii Produced by: Streptomyces narbonensis. Method of extraction: Extraction of culture fluid at pH with ethyl acetate. Transferred into dilute acetic acid. Re-extraction with ethyl acetate after neutralization with sodium carb
. The actinomycetes. Actinomycetales. DEyCRIPTlONS OF ANTIBIOTICS 313 4. Sato, K. and Katagiri, K. Cheinothera})y 5: 182-183. 1957. 5. Miyakawa, T. et al. Japan. J. Microbiol. 2: 53-62, 1958. 6. Hinuma, Y. et al. Jajjan. J. MicTot)iol. 2: 63-68, 1958. 7. Hinuma, Y. et al. Japan. J. Microhiol. 2: 117-125, 1958. 8. An>^ai, O. Vims (Osaka) »: 174-181, 1958. jNarboniyciii Produced by: Streptomyces narbonensis. Method of extraction: Extraction of culture fluid at pH with ethyl acetate. Transferred into dilute acetic acid. Re-extraction with ethyl acetate after neutralization with sodium carbonate. Crude l)ases are chromatographed over alumina. Crystal- lization of active fractions from ether-petroleum ether. Chetuical and pht/sical properties: Colorless crystals; °C. |al„ = +° (c = per cent in chloroform). pK* about in 80 l^er cent methyl Cellosolve (base). C28H47O7N. Belongs probably to the macrolide group of anti- biotics. Maximal light absorption at 225 m/x (log £ = ) and 286 m;u (log e = ). Infrared spectrum given in the original paper (1). Xarbo- mycin yields desosamine on acid hydrolysis. Biological activity: Active against gram-positive bacteria. Cross-resistance with picromycin. Toxicity: LDo (mice) 500 mg per kg subcutane- ously. References: 1. Corbaz, R. et al. Helv. Chim. Acta :}»: 935- 942, 1955. 2. Anliker, R. et al. Helv. Chim. Acta 39: 1785-1790, 1950. Neocide Produced by: Probably an actinomycete. Method of extraction: Dialysis and freeze drying. Cheniirul and physical properties: Stable poly- peptide containing cysteine, arginine, lysine, glycine, cystine, glutamic acid, aspartic acid, serine, alanine, and i)roline. Biological activity: Antitumor and antibacterial activity. Active in mice on Ehrlich ascites car- cinoma and in rats on sarcoma 45. Causes reduc- tion of number of mitotic figures and necrosis in cancer cells. Toxicity: Said to be nontoxic. /^e/erenre; 1. Derkach, V. S. Antibiotiki 2(5): 40-44,
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