. A Reference handbook of the medical sciences embracing the entire range of scientific and practical medicine and allied science . nges; that ascending trophic degen-eration of the sensory nerve branches was present; thatthe degenerative processes involving the nerves spreadover the periphery; and that a central origin cculd beexcluded. In the spinal coid, slight degeneration of theposterior columns was observed, but bacilli were neverfound. He believes with others that in the macules oftrue maculo-ana^sthctic leprosy, either very few or nobacilli are present. Darier* says that all macules ha
. A Reference handbook of the medical sciences embracing the entire range of scientific and practical medicine and allied science . nges; that ascending trophic degen-eration of the sensory nerve branches was present; thatthe degenerative processes involving the nerves spreadover the periphery; and that a central origin cculd beexcluded. In the spinal coid, slight degeneration of theposterior columns was observed, but bacilli were neverfound. He believes with others that in the macules oftrue maculo-ana^sthctic leprosy, either very few or nobacilli are present. Darier* says that all macules havea similar histological structure, and that they all containbacilli, and are of the same nature as the nodules. DuGNOsis.—In well-advanced and typical cases ofeither variety, the diagnosis of leprosy is not dilficiilt,but iu the early manifestations, especially of the maculo- (Aft«r Dom. 48S REFERENCE HANDBOOK OF THE MEDICAL SCIENCES. anastlRtif variety, its reoognition is atteiidc-il with thegreatest difficulty, and iiuniero\is errors in diagnosis arerernnled. In its prodromal stage, lejirosy would prob-.
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