The Journal of biological chemistry . forms a larger percentage of the total non-protein nitro-gen in the plasma than in the whole blood, because of the smallerabsolute amounts of undetermined nitrogen. We have notencountered the very low percentages reported for normal preg-nancy by Folin (4), a failure which has been reported by Case 2, Specimen 1, and in Case 6, Specimens 5 and 6, the higherurea nitrogen: total non-protein nitrogen ratios in the whole bloodare associated with disturbances of the total non-protein nitrogensimilar to those previously noted. The curves of the urea pe
The Journal of biological chemistry . forms a larger percentage of the total non-protein nitro-gen in the plasma than in the whole blood, because of the smallerabsolute amounts of undetermined nitrogen. We have notencountered the very low percentages reported for normal preg-nancy by Folin (4), a failure which has been reported by Case 2, Specimen 1, and in Case 6, Specimens 5 and 6, the higherurea nitrogen: total non-protein nitrogen ratios in the whole bloodare associated with disturbances of the total non-protein nitrogensimilar to those previously noted. The curves of the urea per-centages in Fig. 1 are suggestive, but their interpretation is notclear; although it is apparent that the non-protein nitrogenousmaterials, other than urea, which make up such a large part of thetotal non-protein nitrogen of the corpuscles during the acutetoxemia, are eHminated more rapidly than the urea, so that thepercentage of the latter soon rises to normal. 26 Non-Protein Nitrogenous Constituents 1921 Dec 20 21 22 23. 100 Totdl non-protein N UredN 60 Percentage ^0of non-protein 40N in forrn of 30uredN 20 10 Uric dcid Fig. 1. Graphic chart of results in Case 14. Antepartum eclampsiatreated with morphine. E. D. Plass 27 Uric Acid.—Uric acid is known to be in higher concentrationnormally in the plasma than in the whole blood and Folin (3)even makes the statement that, In the case of uric acid the differ-ence between the figures obtained from whole hjood and fromplasma is so large that practically the whole of the uric acid con-tent of the blood falls on the plasma. We cannot subscribe tothis opinion because we have examined several specimens in whichthe whole blood showed more uric acid than the plasma, indicatingthat the corpuscles contained proportionately more of this sub-stance. Here, too, the actual relation between the blood cells andthe plasma is apparently liable to sudden changes in periods of rapidretention or elimination. For example, in Fig. 1
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