Manual of pathology : including bacteriology, the technic of postmortems, and methods of pathologic research . FlC. 304.—ACHONDKOPLASIA.—(CotiU^y, courtesy oj Dr. HUliJrli Malformation of Bone. In the osseous skeleton many i^erversions ofdevelopment occur. These are usually manifested by defective orperverted bone formation, which may be due to reco},mizable diseases ofthe blood-vessels or may arise without a demonstrable cause. As thelarger part of the osseous skeleton is preceded by a stage of cartilage,anv defect in the laying-down of this priman, enehondral matrix (achon-5^ 8o2 SPECIAL PAT
Manual of pathology : including bacteriology, the technic of postmortems, and methods of pathologic research . FlC. 304.—ACHONDKOPLASIA.—(CotiU^y, courtesy oj Dr. HUliJrli Malformation of Bone. In the osseous skeleton many i^erversions ofdevelopment occur. These are usually manifested by defective orperverted bone formation, which may be due to reco},mizable diseases ofthe blood-vessels or may arise without a demonstrable cause. As thelarger part of the osseous skeleton is preceded by a stage of cartilage,anv defect in the laying-down of this priman, enehondral matrix (achon-5^ 8o2 SPECIAL PATHOLOGY. droplasia) ^ becomes manifest in the later growth and development of thebone. Aside from these defects in the initial process of osseous growth,there is to be recognized, later, certain malformations depending uponfailure in the extent of growth; or it would be better to say the formationof the bone is not completed. Thus, arches may fail to coalesce, as isobserved in the superior maxilla, where developmental arrest gives rise toharehp (see p. 673), cleft palate, etc.; or in the chest, resulti
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