. Bulletin of the Department of Agriculture. Agriculture; Agriculture. Washington, D. C. January 9, 1922 THE RELATIVE TOXICITY OF STRYCHNINE TO THE By Erich W. Schwaetze, Pharmacologist in Charge, Pharmacological Laboratory. CONTENTS. Page. Purpose of investigation 1 Results of previous investigations- 1 Pharmacological action of strych- nine 2 Experimental procedure 7 Results of experimental work : Toxicity of strychnine admin- istered subcutaneously 8 Toxicity of strychnine admin- istered orally 10 Toxicity of diatomaceous earth preparations of strychnine 11 Page. Results of exper
. Bulletin of the Department of Agriculture. Agriculture; Agriculture. Washington, D. C. January 9, 1922 THE RELATIVE TOXICITY OF STRYCHNINE TO THE By Erich W. Schwaetze, Pharmacologist in Charge, Pharmacological Laboratory. CONTENTS. Page. Purpose of investigation 1 Results of previous investigations- 1 Pharmacological action of strych- nine 2 Experimental procedure 7 Results of experimental work : Toxicity of strychnine admin- istered subcutaneously 8 Toxicity of strychnine admin- istered orally 10 Toxicity of diatomaceous earth preparations of strychnine 11 Page. Results of experimental work—Con. Effect of age or development upon toxicity of strychnine- 12 Disposal of strychnine 12 Relative toxicity of strychnine to ground squirrels, mice, and rats 14 Strychnine baits i_- 15 Summary 17 Literature cited 18 PURPOSE OF INVESTIGATION. Strychnine, which heretofore has been regarded with little favor as a poison for rats, was selected as the second of a series of such substances to be studied in the Bureau of Chemistry. The work was designed primarily to ascertain the toxicological conditions under which strychnine will prove efficient and to determine the minimum amounts of this comparatively expensive drug which are required to kill rats. RESULTS OF PREVIOUS INVESTIGATIONS. The literature pertaining to the pharmacology of strychnine is very extensive, but only a few investigators have chosen the rat as an experimental animal. Allard (l)2 cites Savory, who is said to have 1 The experiments discussed in this bulletin constitute the second of a series dealing with substances employed as rat poisons. The first, on barium carbonate, was issued in 1920 as Department of Agriculture Bulletin 915. 2 The figures in parentheses refer to " Literature cited," at the end of this bulletin. 70589°—21 1. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of th
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