Archives of internal medicine . cation. While this method hasproved of great help, it gives us an index of onh one part of the conditionsexisting within the organism, and leaves us entirely without informationin regard to the very important question of the reserve of alkali withinthe body. While the individual differences in alkali content of the bloodand tissues in living beings is at present quite beyond our methods ofinvestigation, it appears that a considerable amount of useful informationmight be obtained if we could measure, in our acidosis patients, not onlythe amount of ammonia that is
Archives of internal medicine . cation. While this method hasproved of great help, it gives us an index of onh one part of the conditionsexisting within the organism, and leaves us entirely without informationin regard to the very important question of the reserve of alkali withinthe body. While the individual differences in alkali content of the bloodand tissues in living beings is at present quite beyond our methods ofinvestigation, it appears that a considerable amount of useful informationmight be obtained if we could measure, in our acidosis patients, not onlythe amount of ammonia that is excreted but also the amount of alkali thatis retained. The following investigation was undertaken in order to determine,first, whether any variations occurred in acidosis between the amount ofammonia and the amount of base excreted; second, whether such varia-tions, if they occurred, would give us information in regard to the acidneutralizing power of the organism; third, whether the method employed H. M. ADLER~0. BLAKE 481 I. ?53^35 Zr / S/5A Mar y^^yyjsyh^^ttitV:tT-^s Ajor. 482 THE ARCHIVES OF IXTERNAL MEDICINE
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