Gynecology . Fig. 11.—Early Development of the left are two primordial follicles, the upper showing the egg and surrounding follicle epi-thelium ; the lower showing the manner in which the follicle epithelium completely surrounds the middle picture shows the earliest stage of ripening in which the follicle epithelium multipliesinto several layers. The third picture shows a further development of the follicle epithelium and thebeginning of the crescentic clear space containing the liquor folliculi. (After Bumm.) .y*o ,^~ 0% :.. o. ,qo -???? s® P§eV. Fig. 12.—Graafian Foll
Gynecology . Fig. 11.—Early Development of the left are two primordial follicles, the upper showing the egg and surrounding follicle epi-thelium ; the lower showing the manner in which the follicle epithelium completely surrounds the middle picture shows the earliest stage of ripening in which the follicle epithelium multipliesinto several layers. The third picture shows a further development of the follicle epithelium and thebeginning of the crescentic clear space containing the liquor folliculi. (After Bumm.) .y*o ,^~ 0% :.. o. ,qo -???? s® P§eV. Fig. 12.—Graafian Follicle from the Ovary of a Newborn clear space around the layer of epithelium is the result of an artefact in preparing the section. (After von Winckel.) 36 GYNECOLOGY the follicle. The tunica interna is also composed of connective tissue, but ismuch more cellular than the externa. These cells are large and rich in proto-plasm and are epithelioid in character. Toward the end of the ripening stagethey are actually larger than the epithelial cells of the membrana granulosa. Meanwhile the egg also undergoes a change. It becomes surrounded by astrong homogeneous capsule, the zona pellucida. The protoplasm of the eggdoes not come in direct contact with the zona pellucida, there being betweenthe two the so-called perivitelline space, which contains fluid and in which the
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