. Dental materia medica and therapeutics; with special reference to the rational application of remedial measures to dental diseases ... anner. His experiments were conductedon the teeth in the living subject. The lower first molars, havingcentral cavities, were selected for his experimental work, and thesilver nitrate applied in 10, 20, 30 and 40-percent solutions and in 1 Harlan: Dental Cosmos, 1898, p. 287. 2 Truman: Dental Cosmos, 1895, p. 1. s Szabo: Osterreichisch-Ungarische Vierteljahrsschrift fur Zahnheilkunde, 1902, p. 42. 194 PHARMACO-THERAPEUTICS. the pure powdered state. The applic


. Dental materia medica and therapeutics; with special reference to the rational application of remedial measures to dental diseases ... anner. His experiments were conductedon the teeth in the living subject. The lower first molars, havingcentral cavities, were selected for his experimental work, and thesilver nitrate applied in 10, 20, 30 and 40-percent solutions and in 1 Harlan: Dental Cosmos, 1898, p. 287. 2 Truman: Dental Cosmos, 1895, p. 1. s Szabo: Osterreichisch-Ungarische Vierteljahrsschrift fur Zahnheilkunde, 1902, p. 42. 194 PHARMACO-THERAPEUTICS. the pure powdered state. The applications were repeated in somecases up to twenty-five times. In due time the teeth were ex-tracted. After decalcifying and fixing, microscopic sections wereprepared and the following phenomena observed: The contentsof the tubules are, up to a certain depth, destroyed, and smallconcrements, stained deeply black, in the form of debris, are debris is coagulated albumin, bacteria, etc., resulting fromthe action of the silver nitrate, which, on exposure to light, assumesa black color. The dense mass of coagulated silver-albumin. Figure Nitrate Applied to Carious Dentin. Low power. (After Szabo.) checks the further action of silver nitrate. The penetration ofthe silver salts into the diseased dentin is limited to about 1/50 ofan inch; a further penetration could not be observed, no matterhow strong and how often the application was renewed. Onsound dentin the penetration was very superficial indeed. Thatpart of the dentinal fibrils wThich comes in direct contact withthe silver salt is destroyed by coagulation, changing the semi-liquid protoplasmic contents of the tubules into a solid mass ofsilver-albumin, which, on exposure to light, becomes black and CAUSTICS. 195 iasoluble. Beyond this line of demarcation the dentinal fibrilsare not altered, but preserve their normal appearance. The actionof silver nitrate on an albumin solution in vitro produces a densesilver-al


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Keywords: ., bookcentury1900, bookdecade1910, bookpublisherstlou, bookyear1913