Adult-like heart tissue engineered from human pluripotent stem cells contains transverse tubules, the mark of maturity, visible on immunofluorescent images. Researchers can now use induced pluripotent stem cells (iPSCs) to train an adult-like model of human heart muscle by introducing electrical and mechanical stimulation at an early stage. Since this muscle is similar to the adult heart, it could serve as a better model for testing the effects of drugs and toxic substances than current tissue-engineered heart models.

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