. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. Control AST-3 Stretch (mm) Figure 2. Neuromodulation can increase dynamic range. GPR2 firing rate as a function of cpv3a stretch amplitude in control saline and in saline containing 1(T8 M AST-3. sensitivity of GPR2 in a linear fashion, so that essentially the same features in the stimulus are being encoded as under control conditions. Far more interesting is the possibility that AST-3 changes the filtering properties of the neuron. The presence of the peptide might change GPR2 from what is basically
. The Biological bulletin. Biology; Zoology; Biology; Marine Biology. Control AST-3 Stretch (mm) Figure 2. Neuromodulation can increase dynamic range. GPR2 firing rate as a function of cpv3a stretch amplitude in control saline and in saline containing 1(T8 M AST-3. sensitivity of GPR2 in a linear fashion, so that essentially the same features in the stimulus are being encoded as under control conditions. Far more interesting is the possibility that AST-3 changes the filtering properties of the neuron. The presence of the peptide might change GPR2 from what is basically a position detector into a sensor with a response that has a stronger dependence on muscle velocity. GPR2 operates in two modes: the conventional "spiking" mode and a novel "bursting" mode (Katz et ai, 1989). In the spiking mode, which was the behavior shown in Figures 1-3, GPR2 generates spikes only during the stretch and is silent when not under tension. In contrast, in the bursting mode, GPR2 generates bursts of spikes (several seconds in duration) even when no stretch is imposed. In the initial description of the bursting mode, the average burst period was found to be -17 s (Katz et ai, 1989). More recently, burst periods ranging between 12 and 101 s have been reported (Birmingham et 1999). GPR2 can be driven from the spiking mode into the bursting mode though pro- longed muscle activity (Birmingham et a!., 1999). The encoding properties of the neuron in the two modes are complementary. In the spiking mode, the neuron is best able to encode rapidly varying stretches, but not slower ones. In the bursting mode, fast stretches are ignored, while slower stretches (varying over minutes or hours) are encoded in the burst times (Birmingham et <//., 1999). Stretch. mm 2s Control AST-3 CO E E « 1 H 0 -. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearan
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Keywords: ., bookauthorlilliefrankrat, booksubjectbiology, booksubjectzoology
