The chemist and druggist [electronic resource] . cimetidine for long periods anda few reports have suggestedranitidine may have this have also been rarereports of impotence withcimetidine. Mental confusion isanother uncommon side-effectwith H : receptor Cimetidine binds tothe liver P450 microsomalenzyme system and so retardsthe breakdown of drugsnormally metabolised by thisroute, leading to increasedplasma concentrations. Themost clinically important effects the symptoms of the underlyingdisease. There was some initialconcern about development ofcarcinoids
The chemist and druggist [electronic resource] . cimetidine for long periods anda few reports have suggestedranitidine may have this have also been rarereports of impotence withcimetidine. Mental confusion isanother uncommon side-effectwith H : receptor Cimetidine binds tothe liver P450 microsomalenzyme system and so retardsthe breakdown of drugsnormally metabolised by thisroute, leading to increasedplasma concentrations. Themost clinically important effects the symptoms of the underlyingdisease. There was some initialconcern about development ofcarcinoids in the acid-secretingcells of rats, but this was foundnot to be caused by the drug butby the reduction of acid, anddoes not occur in Enhances theeffects of warfarin andphenytoin. 3. Selectiveantimuscarinics Pirenzepine (Gastrozepin)inhibits gastric acid and pepsinsecretion. It is as effective as H,receptor antagonists in healinggastric and duodenal ulcer, andcan be used in conjunction withthese agents in resistant cases. It. Healing gastric ulcer (stellate scar) are likely to occur with oralanticoagulants, phenytoin,theophylline and intravenouslignocaine, all of which have afairly narrow therapeutic Acid (proton) pumpinhibitors Omeprazole (Losec) inhibitsgastric acid by blocking thehydrogen-potassium adenosinetriphosphatase enzyme systemof the gastric parietal cell. Ittherefore acts specifically at thefinal step of acid rates and relief ofsymptoms are better than withH 2 antagonists as omeprazole isa more effective anti-secretoryagent. Although in mostcountries the drug is accepted asa first line treatment for gastricand duodenal ulcers, the UKData Sheet says it is indicatedonly for those ulcersunresponsive to conventionaltherapy, including those due toNSAIDs, and that long termtreatment is not , an announcementconcerning the terms of the UKlicence is expected this Contra-indicated inpregnancy and
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Keywords: ., bookcentury1800, bookdecade185, booksubjectpharmacy, bookyear1859
