The Journal of laboratory and clinical medicine . n of the available ciiolesterin forthe formation of the reproductive cells. SUMM.\RY. 1. Clinical data and experimental observation alike suggest that the causativefactor in the production of malignant proliferation is widely distributed within the organism. 674 The Journal of Laboratory and Clinical Medicine 2. There is reason to believe that this fundamental factor is chemical in its nature. 3. The existence of a gradual transition between normal, reparative, benignand malignant proliferation has been commented on by many observers. 4. The ev
The Journal of laboratory and clinical medicine . n of the available ciiolesterin forthe formation of the reproductive cells. SUMM.\RY. 1. Clinical data and experimental observation alike suggest that the causativefactor in the production of malignant proliferation is widely distributed within the organism. 674 The Journal of Laboratory and Clinical Medicine 2. There is reason to believe that this fundamental factor is chemical in its nature. 3. The existence of a gradual transition between normal, reparative, benignand malignant proliferation has been commented on by many observers. 4. The evident connection observed between an increase of cholesterin andproliferation, both normal and abnormal, seems to suggest that cholesterin mayact as a stimulant to cell-division. 5. After puberty and under normal conditions the process of cell-divisionis constantly demonstrable in the sex glands. 6. Recent investigations have shown that the sex glands appear to takean active (perhaps a prominent) part in the regulation of cholesterin Fig. 20.—(Same as Fig. 18.) Sarcomatous portion of the tumor. ( x 800 diam.) As cholesterin is stored in considerable quantities in the corpus luteum duringpregnancy, and increases in the blood after castration, it seems permissible toassume that it may in some way stimulate the formation of the generative cells. CONXLUSIOX. These observations, the fact that the cancer age coincides wdth the cessationof reproductive activity as shown by the cancer statistics (Prinzing^*), the im-portance of metabolism emphasized by Hoffmann in his statistical review on thecancer rates of the \\estern Hemisphere, and the influence of heredity (the trans-mission of inadequate organs) established by the w^ork of Slye,^^ all seem tosupport the view that the retention of cholesterin due to its insufficient conversionor defective elimination may be a primary factor in the etiolog} of malignantdisease. BIBLIOGRAPHY. iColey, W. D.: (Discussion of Elliot,
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