. Bulletin of the Department of Agriculture. Agriculture; Agriculture. yt^'^^V't. BULLETIN No. 405 Joint contribution from the Bureau of Plant Industry WM. A. TAYLOR, Chief, and the Bureau of Animal Industry, A. D. MELVIN, jTU^^W-tv Washington, D. C. PROFESSIONAL PAPER December 5, 1916 LUPINES AS POISONOUS PLANTS. By C. D. Marsh and A. B. Clawson, Physiologists, Drug-Plant and Poisonous-Plant Investigations, Bureau of Plant Industry, and Hadleigh Marsh, Veterinary In- spector, Bureau of Animal Industry. CONTENTS. Part I.—Introduction 1 Summary of knowledge of lupines as poisonous
. Bulletin of the Department of Agriculture. Agriculture; Agriculture. yt^'^^V't. BULLETIN No. 405 Joint contribution from the Bureau of Plant Industry WM. A. TAYLOR, Chief, and the Bureau of Animal Industry, A. D. MELVIN, jTU^^W-tv Washington, D. C. PROFESSIONAL PAPER December 5, 1916 LUPINES AS POISONOUS PLANTS. By C. D. Marsh and A. B. Clawson, Physiologists, Drug-Plant and Poisonous-Plant Investigations, Bureau of Plant Industry, and Hadleigh Marsh, Veterinary In- spector, Bureau of Animal Industry. CONTENTS. Part I.—Introduction 1 Summary of knowledge of lupines as poisonous plants 1 Distribution of lupines 4 Common names of lupines 4 Alkaloids of lupines 5 Ictrogen 6 Part II.—Experimental wore 7 Pharmacological investigations by Soll- mann 7 Field experiments with lupines 13 Laboratory experiments with extracts of lupine seed upon mice 25 Part ni.—Discussion and general con- clusions 28 Failure to poison sheep in 1910,1911, and 1912 28 Lupine not a cumulative poison 29 Page- Part III.—Discussion, etc.—Continued. Toxicity of different species of lupine 30 Toxicity of lupine leaves for sheep 30 Toxicity of lupine seed for sheep 31 Toxicity of lupine pods for sheep 32 Toxicity of lupine fruit for sheep 32 Symptoms 33 Pathology 36 Comparison of "lupinosis" and poisoning of sheep by American lupines 36 Remedies 38 Range conditions under which sheep are poisoned 39 Treatment of range animals to avoid poisoning 41 Summary 42 Literature cited 43 I i PART L—INTRODUCTION. SUMMARY OF KNOWLEDGE OF LUPINES AS POISONOUS PLANTS. EARLY HISTORY AND LATER STUDIES. 1'ho lupines have been known from very ancient times, and are mentioned by many authors, e. g., Theophrastus, Marcus Fortius Cato Censorius, and Phny. The last-named author (ed. 1856, pp. 49-50, 452-453)^ treats of the lupine at length, especially with reference to its use as a green manure. Several species have been used as culti- vated crops in P^urope, more especially for the recl
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