. The thyroid gland in health and disease. thers which are less severe some variable amount of paren-chyma tissue and vesicles may be found. In the myxoedema ofadults the thyroids function is rarely wholly suppressed, butis so diminished as to bring about the infiltration of the tissueswhich is characteristic of this condition. Parathyroid Glands.—It is uncertain to what extent theseare involved in the process which gives rise to myxoedema, but the 174 MYXCEDEMA fact that tetany is a frequent manifestation in goitrous women inthe Himalayas who are the subjects of partial myxoedema, andthat man
. The thyroid gland in health and disease. thers which are less severe some variable amount of paren-chyma tissue and vesicles may be found. In the myxoedema ofadults the thyroids function is rarely wholly suppressed, butis so diminished as to bring about the infiltration of the tissueswhich is characteristic of this condition. Parathyroid Glands.—It is uncertain to what extent theseare involved in the process which gives rise to myxoedema, but the 174 MYXCEDEMA fact that tetany is a frequent manifestation in goitrous women inthe Himalayas who are the subjects of partial myxoedema, andthat many cretins show signs of extensive involvement of thecentral nervous system which are referable at least in part tolesions of the parathyroids, indicate that in myxoedema they donot always escape involvement. Fig. 71 shows the fibroticremains of the parathyroid in a case of long standing. Thesection is from the collection of specimens belonging to thelate Sir Victor Horsley. Forsyth has reported a case of myxoedema in a woman of f -^^ ,v. Fig. 71.—Remains of the parathyroid from a case of myxoedema. Pronouncedatrophy of parenchyma cells and great increase of fibrous tissue. (From a specimenin the possession of the late Sir Victor Horsley, ) forty-eight in whom, in addition to vesicle and colloid formation,there was an abnormal increase in the connective tissue of theparathyroids and a thickening of their artery walls. Changes in the parathyroid glands have also been describedin four cases of myxoedema by Kojima, in two of which therewere evidences of vv^hat he considers to be hyperaction in theshape of vesicle and colloid formation. Of two others the para-thyroids were necrotic in one ; in the other the left parathyroidwas lessened in functional capacity by coagulation necrosis, while THE PITUITARY BODY 175 the right showed the above-mentioned evidences of increasedfunctional action, i Mott also has recorded a similar instance of so-called substi-tutive increase in col
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