The diseases of infants and children . e heart often weak, and pros-tration decided. There is severepain, swelling, tension, and itchingof the face, neck and eyes may be closed and nasalrespiration obstructed; the face soswollen that the patient is unrecog-nizable. Restlessness, sleepless-ness, and delirium are throat is sore and swallowingdifficult, thirst excessive, the tongueparched, the breath foul, the teethand gums covered with sordes,diarrhea may occur, and conjunctivitis and cough are common. Theurine often contains albumin and casts. The discharging pus from
The diseases of infants and children . e heart often weak, and pros-tration decided. There is severepain, swelling, tension, and itchingof the face, neck and eyes may be closed and nasalrespiration obstructed; the face soswollen that the patient is unrecog-nizable. Restlessness, sleepless-ness, and delirium are throat is sore and swallowingdifficult, thirst excessive, the tongueparched, the breath foul, the teethand gums covered with sordes,diarrhea may occur, and conjunctivitis and cough are common. Theurine often contains albumin and casts. The discharging pus fromruptured lesions produces a very offensive odor. The pain which theswelling of the skin occasions at this period is often intense and everymovement or even the pressure of the bed or the bed-clothes may bethe cause of great suffering. The blood in small-pox exhibits a diminution of hemoglobin earlyin the disease. The red blood-corpuscles tend to form irregular clumpsinstead of rouleaux. Magrath, Brinkerhoff & Bancroft^ confirm the. Fig 77.—Discrete Small-pox with E., aged 5 years. Never vac-cinated. Mar. 2, nausea, headache, achingin legs and back, fever; Mar. 5, ameliorationin symptoms, papular rash developing onface; Mar. 7, decided fall of temperature,vesicles appearing; Mar. 10, rise of tempera-ture with pustular stage. From a patientin the Philadelphia Hospital for ContagiousDiseases. Courtesy of Dr. B. Franklin Royer. 1 Journ. Med. Research, 1904, XI, 247. VARIOLA 369 observations of previous investigators, that a varying degree of leucocy-tosis, especially of the mononuclear cells, is present during the eruptivestage. Period of Desquamation.—Drying begins about the 11th or 12thday of the eruption, generally first in the lesions which were first to the 14th or loth day, in average cases, this process is well under waj^,and the crusts begin to fall. Many, however, are very adherent and donot separate until during the 4th week or later, unl
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