. The biosynthesis of proteins. Proteins -- Synthesis. ROLE OF NUCLEIC ACIDS 77 can even release the inhibition produced by azaguanine and completely restore protein synthesis and bacterial growth if added some time after the inhibition by azaguanine is established. Under those conditions, a large part of the azaguanine that had been incorporated into RNA is rejected and found in the medium mostly as azaguanosine (Matthews and Smith, 1956; Smith and Matthews, 1957; Mandel, 1957; Mandel and Markham, 1958). Restoration of protein synthesis by guanosine, however, becomes more and Penicillinase 75
. The biosynthesis of proteins. Proteins -- Synthesis. ROLE OF NUCLEIC ACIDS 77 can even release the inhibition produced by azaguanine and completely restore protein synthesis and bacterial growth if added some time after the inhibition by azaguanine is established. Under those conditions, a large part of the azaguanine that had been incorporated into RNA is rejected and found in the medium mostly as azaguanosine (Matthews and Smith, 1956; Smith and Matthews, 1957; Mandel, 1957; Mandel and Markham, 1958). Restoration of protein synthesis by guanosine, however, becomes more and Penicillinase 750-. 120 240 min 120 240 min Fig. 22. Restoration by guanosine of the synthesis of protein material (a) and of constitutive penicillinase (b), in B. cereiis after azaguanine inhibition. The numbers at the end of the curves indicate the time in minutes elapsed between the additions of azaguanine and of guanosine (Chantrenne and Devreux, 1960). more sluggish when the period of azaguanine inhibition increases. An unexpected feature of the recovery of protein synthesis under the action of guanosine is that the synthesis of an enzyme like constitutive penicillinase is not restored at the same time as net synthesis of the average protein material. This is illustrated in Fig. 22. For instance, when guanosine is added 45 min after the analogue, the synthesis of protein is rapidly restored, whereas penicillinase formation is not yet restored 2 hrs. later (Chan- trenne, 1959; Chantrenne and Devreux, 1960). There is evidence that. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Chantrenne, H. Oxford, New York, Pergamon Press
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