. Ciba Foundation Symposium on Transplantation. Transplantation of organs, tissues, etc. 364 PAUL S. RUSSELL injection of sensitized cells at 5 days of life was particularly bene- ficial appears in Fig. 11. The variation in effectiveness of this late cell treatment appears to occur largely between Utters rather than S4 o m 5 DAY Cell Reeciuipment. DBA sens cells l/V 2 4 6 8 10 12 16 20 24 DAYS of AGE Fig. 11. Individual weight-gain records of a litter of 6 newborn C57BL/6 mice all of which received an intra- venous injection of 12 million DBA/i spleen cells at birth. On the fifth day of life f
. Ciba Foundation Symposium on Transplantation. Transplantation of organs, tissues, etc. 364 PAUL S. RUSSELL injection of sensitized cells at 5 days of life was particularly bene- ficial appears in Fig. 11. The variation in effectiveness of this late cell treatment appears to occur largely between Utters rather than S4 o m 5 DAY Cell Reeciuipment. DBA sens cells l/V 2 4 6 8 10 12 16 20 24 DAYS of AGE Fig. 11. Individual weight-gain records of a litter of 6 newborn C57BL/6 mice all of which received an intra- venous injection of 12 million DBA/i spleen cells at birth. On the fifth day of life four animals (solid dots) received a second intravenous injection of 18 million spleen cells from adult C57BL/6 mice which had pre- viously rejected skin grafts from DBA/i donors. This is a particularly favourable example of the protective effect which can be achieved by a relatively late injection of sensitized cells. within a single litter and may be attributable in part to differences in the immunological capacity of the cells used in different experi- ments. Microscopic examination of the spleens and lymph nodes of surviving animals treated in this way at about 4 weeks of age reveals considerable hyperplasia with many active germinal centres. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Ciba Foundation Symposium on Transplantation (1961 : London, England); Wolstenholme, G. E. W. (Gordon Ethelbert Ward); Cameron, Margaret P. Boston, Little, Brown
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