Degeneration of Smallpox Virus, 2 of 3, TEM
Negatively-stained transmission electron microscopic (TEM) images revealed some of the ultrastructural morphology depicting the sequential degeneration of variola virus particles. Smallpox is believed to have emerged in human populations about 10,000 BC. Infection with smallpox is focused in small blood vessels of the skin and in the mouth and throat before disseminating. In the skin it results in a characteristic maculopapular rash and, later, raised fluid-filled blisters. After vaccination campaigns throughout the 19th and 20th centuries, the WHO certified the global eradication of smallpox in 1979. The last naturally occurring case of smallpox (Variola minor) was diagnosed in 1977.
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