. The Biochemistry of B vitamins. Vitamins; Vitamin B complex. RIBOFLAVIN 679 Flavin-adenine-dinucleotide prevents the toxicity of the diamino- phenazine for Lactobacillus casei in a manner analogous to riboflavin, and is equally Atebrin, Quinine and Related Antimalarials. The discovery that ate- brin inhibits the oxygen consumption of various organisms resulted in investigations of possible relationships to the riboflavin ,59, 60 It was demonstrated that atebrin inhibits D-amino acid oxidase60 and prevents the combination of the apoenzyme of cytochrome reductase with
. The Biochemistry of B vitamins. Vitamins; Vitamin B complex. RIBOFLAVIN 679 Flavin-adenine-dinucleotide prevents the toxicity of the diamino- phenazine for Lactobacillus casei in a manner analogous to riboflavin, and is equally Atebrin, Quinine and Related Antimalarials. The discovery that ate- brin inhibits the oxygen consumption of various organisms resulted in investigations of possible relationships to the riboflavin ,59, 60 It was demonstrated that atebrin inhibits D-amino acid oxidase60 and prevents the combination of the apoenzyme of cytochrome reductase with riboflavin-5' Although riboflavin-5'-phosphate at a CH30 CH CH2 CH2 CH—CH=CH2 I I I HOCH—CH CH2 CH2 /. quinine CH30 CH3 C2Hg NH—CH—CH2—CH2—CH2—N I \ I C2H6 atebrin ratio of 1 to 500 prevents the inhibitory action of atebrin, the inhibition resulting when atebrin is added to the apoenzyme of cytochrome reduc- tase prior to the coenzyme is not affected by the A study of the effect of a number of compounds on the D-amino acid oxidase system has revealed that a large number of compounds related to quinine and atebrin inhibit the Since increased concentrations of flavin-adenine-dinucleotide prevent the inhibition resulting from a number of these compounds, competitive inhibition is indicated. The rela- tive activities of these compounds as compared with quinine at two dif- ferent temperatures are indicated in Table 40. Atebrin, auramine, and novalauramine are somewhat more effective than quinine, while plas- mochin and a number of quinoline derivatives are approximately as. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Williams, Roger John, 1893-. New York : Reinhold Pub. Corp.
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