Studies in cardiac pathology . as typhoid and rheumatic fevers,and certain chronic infections, such as rheumatoid arthritis, oftenseem to produce arteriosclerosis. Three more or less distinct types of arteriosclerosis of the larger vesselsoccur in man: (1) The ordinary nodular form; (2) dilatation of the vessels withincreased tortuosity, the peripheral arteries being of the pipe-stem variety,and (3) the syphilitic type, affecting chiefly the ascending aorta, in which thenodules eventuallj^ cause depressions in the intima. This is primarily a mes-aortitis, with wasting of the media, and with th
Studies in cardiac pathology . as typhoid and rheumatic fevers,and certain chronic infections, such as rheumatoid arthritis, oftenseem to produce arteriosclerosis. Three more or less distinct types of arteriosclerosis of the larger vesselsoccur in man: (1) The ordinary nodular form; (2) dilatation of the vessels withincreased tortuosity, the peripheral arteries being of the pipe-stem variety,and (3) the syphilitic type, affecting chiefly the ascending aorta, in which thenodules eventuallj^ cause depressions in the intima. This is primarily a mes-aortitis, with wasting of the media, and with thickening of the other coats. In 1,000 consecutive autopsies Brooks- found coronary sclerosis of sufficientdegree to seriously affect the nutrition of the heart in 270 cases. The earliestinstance occurred in a boy of fifteen years, the average age being forty-five following associated conditions were found: Chronic alcoholism, 107;. Foster: Jour. Med. Research, Sept., Brooks: New York Med. Jour., 1906, p. Fig. —Ball Thkombus in the Left largo, dark, ball-shaped thrombus lies free in the left auricular cavity. Numeroussmaller mural thrombi are seen enmeshed in the columna; cameae and chorda; tendinea;.The left ventricular wall, which is elsewhere hypertrophied, is noticeably thinned near fPhotOKraph by Dr. .Vlfred R. Allen.) 186 STUDIES IN CARDIAC PATHOLOGY nephritis, 35; syphilis, 30; tuberculosis, 20; carcinoma, 1; diabetes, 6; plumb-ism, 2. All but 15 showed macroscopic myocardial lesions. In 215 cases thesechanges were sufficient to be considered as contributory to the cause of following lesions were observed: Brown atrophy, 64; fibrosis, 24; hyper-trophy, 35; acute dilatation, 20; aneurism, 2; cardiac rupture, 2. At thePhiladelphia General Hospital, which is very rich in such material, among 8,640autopsies the following myocardial lesions were encountered: Acute suppurativemyocarditis, 5; myocardial thrombosis, 28; s
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