Diagnostic methods, chemical, bacteriological and microscopical, a text-book for students and practitioners . NE. 343 Further investigations have shown that cystinuria is really a disturbanceof the amino-acid metabolism. Of the end-products of protein hydrolysiswhich arise in the system, the cystinuric cannot avail himself in the normalway of the cystin, and in part excretes it; the remaining products of proteinhydrolysis undergo their ordinary fate. If free monomolecular a-aminoacids appear in places which are at present not well known, or if they occurthere even in unusual amounts, then, unl
Diagnostic methods, chemical, bacteriological and microscopical, a text-book for students and practitioners . NE. 343 Further investigations have shown that cystinuria is really a disturbanceof the amino-acid metabolism. Of the end-products of protein hydrolysiswhich arise in the system, the cystinuric cannot avail himself in the normalway of the cystin, and in part excretes it; the remaining products of proteinhydrolysis undergo their ordinary fate. If free monomolecular a-aminoacids appear in places which are at present not well known, or if they occurthere even in unusual amounts, then, unlike the normal individual, the cystin-uric is unable to burn them and they leave the organism unchanged justas cystin itself does. The basic diamine acids behave in practically the sameway, except that the CO2 group is split off from them and we arrive at diam-inuria (Neuberg). Crystals of cystin are rare in the urinary sediment. In some of the casesreported the cystin did not separate from the urine until this was acidified withacetic acid and allowed to stand for 12 hours. It crystallizes in two forms:. Fig. 97.—Pure leucin. {Hawk.) (i) six-sided tablets having an opalescent luster and sometimes traced withfine lines of secondary crystallization; (2) four-sided square prisms lyingseparately or in stellate forms. These crystals are soluble in hydrochloricacid, alkahne hydrates, and insoluble in acetic acid. These tests differentiateit from uric acid. If the lurinary sediment suspected of containing cystin betreated with strong sodium hydrate solution and a few drops of benzoyl chlorid,and the mixture shaken, a voluminous precipitate of benzoyl cystin is obtained. (7). Leucin (^). Chemically leucin is a-aminoisobutylacetic acid. It occurs in theurine in conditions associated with more or less marked derangement of hepaticfunction (see amino acids). As found in the urine, leucin appears in the formof yellowish, highly refractile spherules, with alternating light and dar
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