. Biological structure and function; proceedings. Biochemistry; Cytology. MITOCHONDRIAL LIPIDS AND THEIR FUNCTIONS IN THE RESPIRATORY CHAIN 187 Experiments with antimycin A, which inhibits oxidation of ubiquinol, have shown that the enzymically reducible ubiquinone is only 80-90*;'o of the total. Thus succinate in State 4 is actually giving complete reduction Oi2r. 260 280 300 Wavelength (m//) Fig. I. Steady-state oxidation-reduction levels of ubiquinone in rat-liver mitochondria. — ^_^— total ubiquinone (oxidized); — ?— total ubiquinone reduced with XaBHj; — X— Pi-hair; — A— Pj + ADP + air; —
. Biological structure and function; proceedings. Biochemistry; Cytology. MITOCHONDRIAL LIPIDS AND THEIR FUNCTIONS IN THE RESPIRATORY CHAIN 187 Experiments with antimycin A, which inhibits oxidation of ubiquinol, have shown that the enzymically reducible ubiquinone is only 80-90*;'o of the total. Thus succinate in State 4 is actually giving complete reduction Oi2r. 260 280 300 Wavelength (m//) Fig. I. Steady-state oxidation-reduction levels of ubiquinone in rat-liver mitochondria. — ^_^— total ubiquinone (oxidized); — ?— total ubiquinone reduced with XaBHj; — X— Pi-hair; — A— Pj + ADP + air; —O— Pi +succinate-I-air; —•— Pj + succinate-I-ADP + air. of the enzvmicallv active material, while /S-hydroxybutyrate in State 4 is giving about 80",, reduction. These changes are qualitivelv similar to those reported by Chance [21] for guinea-pig kidnev mitochondria and support the view that the oxida- tion of ubiquinol is blocked in the absence of a phosphate acceptor by an inhibitorv interaction which could involve energy conservation as a high- energv intermediate UQIL^I bv a series of reactions as follows: UQ + I - (i) UQ. I + FPH., = - I + FP (2) UQH.,^I^X =UQH., + I-X (3) I~X + ADP + P, -X+I + ATP (4). Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original IUB/IUBS International Symposium (1st : 1960 : Stockholm); International Union of Biochemistry; International Union of Biological Sciences; Goodwin, T. W. (Trevor Walworth); Lindberg, Olov, 1914-. London, New York, Academic Press
Size: 1433px × 1744px
Photo credit: © Library Book Collection / Alamy / Afripics
License: Licensed
Model Released: No
Keywords: ., bookcentury1900, bookcollectionbiodiver, booksubjectbiochemistry
