. University of Toronto studies. Physiological series. no. 1-98. 1900-28 . ood pressure. In order todetermine whether the abnormal responsewas due to anocain a cat (weight kgms.)was gently fastened to the board withoutits being alarmed. Then a solution ofanocain ( gram) was injected into theskin and later the muscles on either side ofthe femoral artery. Adrenalin, 1:100,000was injected into the femoral vein. Bloodpressure was registered from the femoralartery; cc. caused a rise of 15 mm. from180 mm.; cc. increased the blood pres-sure 26 mm. from 192 mm., (see fig. 9).Following
. University of Toronto studies. Physiological series. no. 1-98. 1900-28 . ood pressure. In order todetermine whether the abnormal responsewas due to anocain a cat (weight kgms.)was gently fastened to the board withoutits being alarmed. Then a solution ofanocain ( gram) was injected into theskin and later the muscles on either side ofthe femoral artery. Adrenalin, 1:100,000was injected into the femoral vein. Bloodpressure was registered from the femoralartery; cc. caused a rise of 15 mm. from180 mm.; cc. increased the blood pres-sure 26 mm. from 192 mm., (see fig. 9).Following this the cat was placed underthe influence of ether. Thirty minutes afterthe above reaction with anocain anaesthesia, cc. adrenalin produced a fall of 10 blood pressure (from 175 mm.) while decreased the blood pressure 24 mm. (from 173 mm.). One hour after anocain had been given, cc. adrenalin produced afall of 33 mm. (from 175 mm., see fig. 9). Anocain was again givenintramuscularly after which adrenalin produced nothing but a rise inblood Fig. 9. Reversal of bloodpressure response to 1 : 100,000, after in-jecting anocain. a, Beforeinjecting anocain; b, after in-jection of anocain. Catweighing kgms. (Re-duced 4.) MECHANISM OF ADRENALIN VASODILATATION 365 After sufficient time had elapsed the fall in blood pressure again re-turned upon the injection of the usual dose of adrenalin. This experiment was repeated in another cat with similar would conclude that anocain inhibits the action of the adrenalinvasodilator mechanism. There is some evidence that dilatation of a limb may be preventedby afferent impulses from that part. Many of the experiments whichgave no dilatation from adrenalin in the normal limb were performed ina cold laboratory (15°C. or less). Although the operating table waswarmed, the limbs were never as warm as the back of the the temperature was much lower than in most of our successful
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