. Bulletin of the Museum of Comparative Zoology at Harvard College. Zoology. 10 13 15 Days After Injury Figure 3. Volume fraction of compact bone at the site of in- jury to the rat tibia at different time intervals postinjury. Note less compact bone in the control nonirradiated rats (dashed columns) as compared to low-energy laser-irradiated rats (sol- id columns). *P < ; **P < posure to He-Ne laser irradiation (during the regeneration process) in both toads and rats, although in the toads the pro- motion effect was higher. We have recent- ly shown that LELI promotes proliferat
. Bulletin of the Museum of Comparative Zoology at Harvard College. Zoology. 10 13 15 Days After Injury Figure 3. Volume fraction of compact bone at the site of in- jury to the rat tibia at different time intervals postinjury. Note less compact bone in the control nonirradiated rats (dashed columns) as compared to low-energy laser-irradiated rats (sol- id columns). *P < ; **P < posure to He-Ne laser irradiation (during the regeneration process) in both toads and rats, although in the toads the pro- motion effect was higher. We have recent- ly shown that LELI promotes proliferation of satellite cells from skeletal muscle origin grown in culture (Ben-Dov et al., 1999). These cells are considered to be the stem cells for muscle regeneration and, there- fore, their enhanced proliferation by LELI in vitro may explain the enhanced kinetics of regeneration in vivo, as demonstrated in the present study. Because we have pre- viously found that LELI also proinotes new blood vessel formation (angiogenesis) at the site of skeletal inuscle regeneration (Bibikova et al., 1994), it might be postu- lated that a better oxygen and nutrient supply will also contribute to enhancement of the regeneration. Assia et al. (1989) sug- gested that in the case of optic nerve re- generation after crush injury, LELI acts to slow degenerative processes rather than promoting regeneration, and that the ef- fect of laser irradiation is transient and subsides markedly when irradiation ceases. In the present work, the effect of laser ir- radiation was not transient because the ainount of newly formed young myofibers was twofold higher in the injured zone of experimental rats after two subsequent la- ser irradiations. Tissue reaction to injury in cranial nerves and skeletal muscles is most probably entirely different and they may react differently to laser irradiation. The results of the present study also indicate. Figure 4. Light micrographs of longitudinal section of the injured zone
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