. Control mechanisms in cellular processes. Cytology; Biochemistry. 154 CONTROL MECHANISMS IN CELLULAR PROCESSES Such a mechanism of control would once more manifest itself as inhibition at the triose phosphate dehydrogenase level, with a con- sequent fluctuation of fructose diphosphate. It fails to explain the lowering of glucose uptake seen in aerobic glycolysis. The effect of subtle changes in DPNH removal may be enhanced by varying phosphate concentrations and ADP concentrations, thus supplving n LU (J) if) LU > iLl o z < X o LACTATE. yU-M PHOSPHATE ADDED Fig. 5-
. Control mechanisms in cellular processes. Cytology; Biochemistry. 154 CONTROL MECHANISMS IN CELLULAR PROCESSES Such a mechanism of control would once more manifest itself as inhibition at the triose phosphate dehydrogenase level, with a con- sequent fluctuation of fructose diphosphate. It fails to explain the lowering of glucose uptake seen in aerobic glycolysis. The effect of subtle changes in DPNH removal may be enhanced by varying phosphate concentrations and ADP concentrations, thus supplving n LU (J) if) LU > iLl o z < X o LACTATE. yU-M PHOSPHATE ADDED Fig. 5-2. The effect of increasing phosphate concentrations on aerobic glycolysis and respiration. All flasks contained hexokinase and 30 /xmole 2-deoxyglucose. The remainder of the additions were as described previously (van Eys and Warnock, 1959). The values are corrected for changes in the absence of fructose diphosphate. an interplay of many factors at the sensitive site. It must be noted here, however, that under conditions of low pyruvate it is respira- tion and not glycolysis which is sensitive to low phosphate concen- trations (van Eys and Warnock, 1959). See Fig. 5-2. It is clear that no explanation of the Pasteur effect is completely satisfying at the present time. No choice will be made, nor will any new theories be advanced at this Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Bonner, David M; Society of General Physiologists; Suskind, Sigmund R. New York, Ronald Press
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