The Journal of biological chemistry . he gas there hadf^FiG. 6. Show- occurred a fall in the alkah reserve to changes in the or more below the initial level. This fall in alkalialkali reserve in reserve was associated in Experiment 6 with athe control exper- marked fall in the total [CO2] of the blood withimen so ^*^P pH still above its initial level; in Experiment 7at the third bleeding with a similar fall in alkalireserve the total [CO2] was the same as at the initial observation,but the pH had fallen These differences in total [CO2] and AlK. in controlexperimen
The Journal of biological chemistry . he gas there hadf^FiG. 6. Show- occurred a fall in the alkah reserve to changes in the or more below the initial level. This fall in alkalialkali reserve in reserve was associated in Experiment 6 with athe control exper- marked fall in the total [CO2] of the blood withimen so ^*^P pH still above its initial level; in Experiment 7at the third bleeding with a similar fall in alkalireserve the total [CO2] was the same as at the initial observation,but the pH had fallen These differences in total [CO2] and AlK. in controlexperiments rem.+8 +4 0 -4 -8 •• • • •• •• Cullen, Austin, Kornblum, and Robinson 639 in pH, in spite of similar falls in the level of the CO2 absorptioncurve as measured by the fall in alkali reserve must be attributedto differences in pulmonarj^ ventilation. The position of theblood along the CO2 absorption curves at the third bleeding isquite different in the two experiments, the CO2 tension beingmuch lower in Experiment Fig. 7. Anoxemia.—In order to determine how much of this effectreported above might be attributed to the anoxemia alone,Experiment 8 was performed in which nitrogen was administeredfor 30 seconds followed by a mixture of 95 per cent nitrogen and5 per cent O2. The results corresponded closely with thoseobtained in Experiment 7, except that there was no initial rise inthe calculated alkali reserve. In Experiment 12 in which there 640 Initial Acidosis in Anesthesia was administered 95 per cent nitrogen and 5 per cent oxygen, butat no time pure nitrogen, and in which the unsaturation of theblood probably did not exceed mM. the fall in alkali reserve wasslight if indeed it occurred at all. In the presence of markedanoxemia, therefore, this fall in alkali reserve may occur; on theother hand, a very considerable degree of anoxemia may occurwithout fall in alkali reserve. The fall associated with nitrousoxide is no greater than that occurring with a
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