. Biological transport. Biological transport; Biological Transport. BIOLOGICAL TRANSPORT permit ATP to influence (and perhaps also to respond to) the dis- tribution of electrons within the membrane. This movement of elec- trons is visualized as taking place across a series of fixed molecular sites extending through the membrane. These are taken to be anionic sites able to bind the alkali metal ions. The theory of Eisenman, Rudin, and Casby (see Eisenman, 1961, for references) is used to account for the corresponding movement of a differential affinity for the sodium and potassium ions. Accordi
. Biological transport. Biological transport; Biological Transport. BIOLOGICAL TRANSPORT permit ATP to influence (and perhaps also to respond to) the dis- tribution of electrons within the membrane. This movement of elec- trons is visualized as taking place across a series of fixed molecular sites extending through the membrane. These are taken to be anionic sites able to bind the alkali metal ions. The theory of Eisenman, Rudin, and Casby (see Eisenman, 1961, for references) is used to account for the corresponding movement of a differential affinity for the sodium and potassium ions. According to this theory, an increase in the negative field strength of a chemical grouping can cause its affinity for sodium ion to exceed that for potassium ion. Inversely, a decrease in the negative electrostatic field strength can favor potassium-ion binding. The joining of ATP is supposed to initiate an electron migra- tion away from the most remote alkali metal-binding site to a dis- Outside ^ +. Na+ ATP Inside Figure 29 Visualization adapted from Skou (1961) of Na+ ex- trusion in exchange for K+ across a series of points whose relative affinity for Na+ and K+ is made to change sequentially by the migration of an electron. The arc marked ATP illustrates the hypothetical position of bound Mg2ATP (as in Figure 28) and the direction of the electron movement it induces. See text for discussion. 88. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Christensen, Halvor N. New York, W. A. Benjamin
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