. Transactions of the Southern Surgical and Gynecological Association. Fig. 7.—Same case, showing well-developed sarcoma at site of fracture. X-raytaken two months later. (Case I.) Fig. 8.—Same case after four months treatment with the mixed toxins oferysipelas and Bacillus prodigiosus. Almost complete disappearance of the formation of hone and reunion of pathological fracture. (Case I.) Fig. 9.—Round-celled sarcoma originating in scar (cicatrix) of a hernia operationwithin four weeks after operation. Associated with a sarcoma of upper jaw, occur-ring just before. Caused death in thr
. Transactions of the Southern Surgical and Gynecological Association. Fig. 7.—Same case, showing well-developed sarcoma at site of fracture. X-raytaken two months later. (Case I.) Fig. 8.—Same case after four months treatment with the mixed toxins oferysipelas and Bacillus prodigiosus. Almost complete disappearance of the formation of hone and reunion of pathological fracture. (Case I.) Fig. 9.—Round-celled sarcoma originating in scar (cicatrix) of a hernia operationwithin four weeks after operation. Associated with a sarcoma of upper jaw, occur-ring just before. Caused death in three months. (Case II, see text.) Fig. 10.—Round-celled and spindle-celled sarcoma of superior maxilla. (Case XXXI.). Fia 11.—Round-celled sarcoma of breast. Acute traumatic malignancy. (Case XXXIX.) WILLIAM B. COLEY 281 Period of Time Intervening Between Injury and Appearance of Tumor Less than 1 week 50 1 to 2 weeks 13 2 weeks to a month 54 1 to 2 months 23 2 to 6 months 31 6 to 12 months 15 1 to 2 years 17 2 to 3 years 5 Over 3 years 17 225 The interval elapsing between the injury and the appear-ance of the breast tumor was as follows: Less than 1 week 5 2 weeks to a month 14 1 to 2 months 3 2 to 6 months 8 6 to 12 months 7 1 to 2 years 5 2 to 3 years 3 Over 3 years 7 52 The closest connection between the effect of injury uponsarcoma and carcinoma is found in the group of tumorsclassed as melanotic sarcomas. Nineteen of such cases areincluded in my series in which the development of the tumorfollowed some definite injury, such as the tying off of apigmented mole, or bruising it sufficiently to make it bleed,or burning it with a cautery. Now, this group of tumors is classed by some pathologistsas
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