. Currents in biochemical research. Biochemistry -- Research; Biochemistry; Research. GREGORY PINCUS obtained evidence for its production by human ovaries perfused in vitro. Estradiol is oxidized to estrone by various tissues and estrone is re- duced to estradiol. Which of the two is formed first in the ovary cannot therefore be determined a priori. We need to know the pre- cursor of both to solve the problem. The isolation of estrone (but not estradiol) from adrenal tissue suggests that it may be supplied by the adrenal gland to the ovary for conversion to estradiol. Production of estrone by
. Currents in biochemical research. Biochemistry -- Research; Biochemistry; Research. GREGORY PINCUS obtained evidence for its production by human ovaries perfused in vitro. Estradiol is oxidized to estrone by various tissues and estrone is re- duced to estradiol. Which of the two is formed first in the ovary cannot therefore be determined a priori. We need to know the pre- cursor of both to solve the problem. The isolation of estrone (but not estradiol) from adrenal tissue suggests that it may be supplied by the adrenal gland to the ovary for conversion to estradiol. Production of estrone by the adrenal gland must be in minor amount since the excision of the ovaries in adult animals effectively abolishes the estrous cycle. Furthermore, adrenal- ectomy in animals does not abolish estrous cycles, though irregularities do occur. Finally, Samuels and collaborators have demonstrated that women with Addison's disease (in which the adrenal glands are atro- phied or destroyed) excrete normal amounts of folliculoids. It is clear, therefore, that the adrenal glands are not essential for the produc- tion of folliculoids. It is interesting to note, however, that very early ovariectomy in mice leads to the eventual establishment of estrous cycles and the excretion of notable amounts of folliculoid. Also, the injection of pituitary adrenocorticotropic hormone into ovariectomized rats stimulates folliculoid production by the adrenals. The most likely conclusion is that the capacity for ovarian hormone synthesis is present in adrenal tissue, but that optimal conditions are found in normal ovarian tissue. This remarkable steroidogenic capacity of the adrenal cortex is also confirmed by the isolation in small amounts of progesterone from adrenal extracts. CH3 CH3 CHg c=o HO—J. HgC c=o COH H3C VV (I) A'-Pregnenolone /X (II) Progesterone HO-. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and ap
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