. Cell chemistry; a collection of papers dedicated to Otto Warburg on the occasion of his 70th birthday. Warburg, Otto Heinrich, 1883-; Biochemistry. VOL. 12 (1953) EFFECTS OF INSULIN ON MELANOMA 337. of two S-91 tumors from mice maintained at 40° C for 255 hours had (^co^ values of only and in the absence of additions, and only and respectively in the presence of 4 units of low-zinc insulin plus y inorganic zinc per ml. It is not known whether these tumors were zinc-inhibited [cf. later section and Table IV, columns 3 and 4) or not, but two "room temperature"
. Cell chemistry; a collection of papers dedicated to Otto Warburg on the occasion of his 70th birthday. Warburg, Otto Heinrich, 1883-; Biochemistry. VOL. 12 (1953) EFFECTS OF INSULIN ON MELANOMA 337. of two S-91 tumors from mice maintained at 40° C for 255 hours had (^co^ values of only and in the absence of additions, and only and respectively in the presence of 4 units of low-zinc insulin plus y inorganic zinc per ml. It is not known whether these tumors were zinc-inhibited [cf. later section and Table IV, columns 3 and 4) or not, but two "room temperature" tumors from the same transplant generation, and run simultaneously, showed Q^q^ values of and without insulin and and (respectively) with low-zinc insulin plus zinc. Very prolonged exposure to high temperature at least results in a marked lowering of tumor Q^^, and is associa- ted with pronounced suppression of tumor growth (Fig. 5). Melanoma-bearing mice held at 35° C for varying periods of time, and com- pared with mice held at a uniform tempera- ture of 20° C, also showed much larger insulin-induced stimulations of (2c6, than did the low temperature series (Table II). Here, too, the average control Q^^^ is lowest in the high temperature series, and following the addition of insulin, rises to that of the low temperature series. Again prolonged exposure of the tumors to high temperature (35° C) was associated with a further depression of both (2c6 and growth. Thus in two tumors held for 44 days at 35 ° C there was a marked suppression of growth (Table III), and the (2c6 values were low. In one of these tumors the (2c6, was , and addition of i unit crystalline zinc-insulin per ml raised this value only 12%. The other tumor, which was the more fibrous of the two, had a Q^q^ of only In the latter case insulin increased the rate of acid production 80% [Q^q = 5-5o)- g § -VD\ - t 6 10 12 Days Fig. 5. Growth responses
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