Gynecology . f the earliest embryonaltime some of these cells may be displaced to the most diversified parts of the developing organ-ism. It has been proved by animal experimentation that the earliest segmentation divides theovum into two kinds of blastomeres, those which become the later germ-cells (ova or spermato- 348 GYNECOLOGY zoa) and those which enter into the construction of the body (somatic cells). It is conceivablethat from some irregularity of development and arrangement of the primary cells a somaticblastomere may become displaced and included, for example, in the ovary, where it
Gynecology . f the earliest embryonaltime some of these cells may be displaced to the most diversified parts of the developing organ-ism. It has been proved by animal experimentation that the earliest segmentation divides theovum into two kinds of blastomeres, those which become the later germ-cells (ova or spermato- 348 GYNECOLOGY zoa) and those which enter into the construction of the body (somatic cells). It is conceivablethat from some irregularity of development and arrangement of the primary cells a somaticblastomere may become displaced and included, for example, in the ovary, where it may eitherbe destroyed undeveloped or, under the irritating influence of some chemical change in theblood or surrounding tissue substance, be awakened later from its dormant state into produc-tive activity, and create a dermoid cyst or a teratoma. (Free translation.) Stromatogenous Tumors of the Ovary.—The stromatogenous tumors springfrom the connective-tissue stroma with which the ovary is richly Fig. 147.—Colloid Carcinoma of the Ovary. (Metastatic.)High power. This shows the large cells with the eccentrically placed nucleus characteristicof Krukenbergs tumor. When cut in the right plane, as in the lower right and middle parts of thedrawing, they have the appearance of a seal ring. The benign tumors are represented by the fibromata, which appear eitheras small circumscribed growths or as diffuse neoplasms forming large solidtumors. The circumscribed fibromata represent a local hyperplasia of the ovarianstroma, which in some cases can with difficulty be differentiated from thefibrous changes of an interstitial oophoritis. In other cases the fibromatous
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