Cyclopaedia of the diseases of children, medical and surgical . valence has occasionally been noted, and of theeight cases which I have had the unusual opportunity of investigating (8,9, 10) four occurred in one family, three being the offspring of one womanand one the child of her sister-in-law (8). This observation has the addi-tional interest of suggesting a possible paternal factor in causation, and itwas noteworthy that both the woman and her brother were very pathogenesis, however, of this morbid state is obscure. Some writershave looked for and found a purely foetal cause in
Cyclopaedia of the diseases of children, medical and surgical . valence has occasionally been noted, and of theeight cases which I have had the unusual opportunity of investigating (8,9, 10) four occurred in one family, three being the offspring of one womanand one the child of her sister-in-law (8). This observation has the addi-tional interest of suggesting a possible paternal factor in causation, and itwas noteworthy that both the woman and her brother were very pathogenesis, however, of this morbid state is obscure. Some writershave looked for and found a purely foetal cause in premature closure of theforamen ovale, in aortic stenosis, in absence of the thoracic duct, in cysticdegeneration of the kidneys, in a leucocytic infiltration of liver and kid-neys, and in foetal leukaemia; other authors have discovered a maternalcause in diseased conditions of the blood (hydraemia, anaemia), in nephritis, 1 As has already been pointed out, only such congenital diseases as are not fully con-sidered elsewhere in this work are dealt with 25
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