ORF VIRUS, TEM


Orf virus (colorized TEM, negative-stained, the bar represents 100 nm). Orf virus (Parapoxvirus ovis) is a double-stranded DNA virus of the Poxviridae family. This virus has an oval structure, from 250 to 300 nm in length, with a regular external structure composed of tubules. Infecting the skin of vertebrae, it is a pathogen common to sheep and goat ; human can become infected by contact with an infected animal, (zoonosis). It is contagious pustular dermatitis or contagious ecthyma. Orf > Parapoxvirus > Poxviridae > DNA virus > Virus. This negative-stained transmission electron micrograph (TEM) image depicted the ultrastructural details of an Orf virus, a member of the genus Parapoxvirus. Note the spiral arrangement of the external tubular ridges on the ovoid-shaped virus particle, or virion. The Orf virus is a pathogen common to sheep and goats, but can at times be transmitted to humans, in which case the virus is known as being “zoonotic”. When a human being becomes infected, the symptoms are mainly confined to the skin, and consist of “weeping” nodules manifesting upon the dorsum, or back of the hands, and which heal in approximately thirty-five days in a spontaneous fashion.


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Photo credit: © CDC/C.GOLDSMITH / BSIP / Alamy / Afripics
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