. A study of the causes underlying the origin of human monsters : third contribution to the study of the pathology of human embryos . ion. The specimenwas macerated too much to allow careful microscopic exami-nation. No. 364. Ovum, 90 x 50 x 40 mm.; embryo, 16 mm. Dr. Merrill, Stillwater, Minn. The ovum is covered with a few ragged villi, over whichthere is some decidua which is more or less detached. had placed the specimen in formalin and sent it tome accompanied with the following letter, dated July 6, 1906: 22 340 MALL. [Vol. XIX. Yesterday I sent another specimen by express. It


. A study of the causes underlying the origin of human monsters : third contribution to the study of the pathology of human embryos . ion. The specimenwas macerated too much to allow careful microscopic exami-nation. No. 364. Ovum, 90 x 50 x 40 mm.; embryo, 16 mm. Dr. Merrill, Stillwater, Minn. The ovum is covered with a few ragged villi, over whichthere is some decidua which is more or less detached. had placed the specimen in formalin and sent it tome accompanied with the following letter, dated July 6, 1906: 22 340 MALL. [Vol. XIX. Yesterday I sent another specimen by express. It seemedto me that it would be a good specimen for you. April 7 wasthe date of the last menstruation; the abortion followed onJuly 5, 1906. The first flow and pain appeared on the nightof July 4. The woman has been married four years; this washer first conception. Both she and her husband are veryanxious to have a child, so the miscarriage could not havebeen aided. There was no incident, accident or otherwise togive cause for the abortion. The woman is unusually healthyand the miscarriage took place without chill or rise of tem-. Fig. 364a.—The ovum. Natural size. perature. The specimen was placed in formalin, 10 per cent,within two hours after its expulsion. This history did not satisfy me, so I wrote Dr. Merrillasking a number of questions, for it is from specimens likethis that we may hope to find the cause for such malforma-tions. His second letter, dated October 24, 1906, reads asfollows: This specimen is from the first conception, afterseveral years of married life. The woman had been operatedupon several years ago for appendicitis. She has not beenaltogether regular with her menstrual periods, and there issome pain connected with them. She had been treated, some No. i.] ORIGIN OF HUMAN MONSTERS. 34i


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