Annals of tropical medicine and parasitology . , M. X.) who was subject to blackwater fever, it will be seenthat although nearly every increase in the rate of secretion of urinewas accompanied by an increased rate of excretion of quinine, thequinine was excreted at a smaller concentration. 2. The quinine-content of the blood of the various casessubjected to precisely similar medication shows very great individualdifferences. Compare in Group A, Case 5, with r6, 20, ro and44 mgms. quinine per litre in the successive samples of blood, andCase 8, with i66 mgms. quinine per litre in each sample, e
Annals of tropical medicine and parasitology . , M. X.) who was subject to blackwater fever, it will be seenthat although nearly every increase in the rate of secretion of urinewas accompanied by an increased rate of excretion of quinine, thequinine was excreted at a smaller concentration. 2. The quinine-content of the blood of the various casessubjected to precisely similar medication shows very great individualdifferences. Compare in Group A, Case 5, with r6, 20, ro and44 mgms. quinine per litre in the successive samples of blood, andCase 8, with i66 mgms. quinine per litre in each sample, even thevery first. The various cases differ greatly, not only in the maximalconcentrations attained but also in the rapidity with which themaximum is reached. Further, as has already been pointed out,most of them have less quinine in the third sample than in the first. These differences in the amount of quinine in the blood aredoubtless accompanied by (more or less proportional ?) differencesin the concentration of the quinine in the 400 2800 3200 Ordinates—I I I Urine, secretion rate. Cc. urine in 50 minutes. - Quinine excretion rate. Mgs. quinine in 200 minutes. - Concentration of quinine. Mgms. quinine in i litre of urine 3600 Minutes I I I 255 Graph 11. Case i6. MX. 2150 mgms, quinine by mouth, as quinine sulphate.
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Keywords: ., bookcentury1900, bookdecade1900, booksubjectparasites, bookyear19
