. Radium . a of the sigmoid with metastatic dissemination inthe peritoneum previously reported by one of usl demonstrates theimportance and extent of this connective tissue formation. An explora-tory laparotomy was done on the patient which revealed a carcinoma ofihe sigmoid and a peritoneal disseminat>n wiih minute metastaticnodules. The case was declared to be inoperable and the tumor was notremoved. The patient was treated with massive doses of Roentgenrays for six months; subsequently the patient died from an acute in-testinal obstruction. At the necropsy there were found in the periton
. Radium . a of the sigmoid with metastatic dissemination inthe peritoneum previously reported by one of usl demonstrates theimportance and extent of this connective tissue formation. An explora-tory laparotomy was done on the patient which revealed a carcinoma ofihe sigmoid and a peritoneal disseminat>n wiih minute metastaticnodules. The case was declared to be inoperable and the tumor was notremoved. The patient was treated with massive doses of Roentgenrays for six months; subsequently the patient died from an acute in-testinal obstruction. At the necropsy there were found in the peritonealcavity several loops of the small intestine adherent by old adhesions tothe posterior surface of the tumor mass in the sigmoid. The periton-eum was studded with numerous white plaques, varying in size from1 to 5 mm. in diameter. Microscopic examination of a section takenthrough two loops of the small intestine that were firmly bound to-gether by adhesions showed that the latter consisted of a thick layer. Fig. ( 1) .—Metastatic carcinoma ui a lymph L,land. of connective tissue containing occasional nests of tumor cells. Theperitoneal nodules were composed of dense connective tissue, with oc-casional minute groups of tumor cells. The amount of connectivetissue in these peritoneal nodules of carcinoma was entirely out of pro-portion to the number of carcinoma cells present. On the other hand,the peritoneal endothelium of the sections of the wall of the small in-testine adjacent to the plaques was normal and showed no connectivetissue formation. The source of the new connective tissue formed under the in-fluence of the radium and Roentgen rivs nuist be looked for eilherin the stroma of the tumor or in the round cell infiltration that closelyfollows the destniction of the tumor cells by the radiations. It may 1. Levin. Isaac: Surg., Gynec. and , 21, 37-). Radium 25 be stated then that while the destruction of the tumor cells is the pri-mary phase and the forma
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Keywords: ., bookauthorcameronw, bookcentury1900, bookdecade1910, bookyear1913
