. Adventures in radioisotope research;. Radioactive tracers; Radiobiology. •618 ADVENTURES IN RADIOISOTOPE RESEARCH In another experiment we administered a physiological dose of adre- naline to the recipient rabbit, infusing all through the experiment ml •of saline per min containing 1 y of adrenahne per kgm body weight. 42- 28- 14. aarenoline dose Pharmacological adrenaline dose I fiO 1 120 Time m minutes ~i— 160 240 Fig. 3. Effect of injection of adrenaline on the rate of extrusion of ^^Fe from the plasma of the rabbit. In both experiments a marked increase of the disappearance of ^^Fe f
. Adventures in radioisotope research;. Radioactive tracers; Radiobiology. •618 ADVENTURES IN RADIOISOTOPE RESEARCH In another experiment we administered a physiological dose of adre- naline to the recipient rabbit, infusing all through the experiment ml •of saline per min containing 1 y of adrenahne per kgm body weight. 42- 28- 14. aarenoline dose Pharmacological adrenaline dose I fiO 1 120 Time m minutes ~i— 160 240 Fig. 3. Effect of injection of adrenaline on the rate of extrusion of ^^Fe from the plasma of the rabbit. In both experiments a marked increase of the disappearance of ^^Fe from the circulation was observed under the action of adrenaline, the effect of a pharmacological dose being the more pronounced one. DISCUSSION Following injection of labelled ions into the jugular vein there is a large arteriovenous concentration difference which decreases exponenti- ally with time (Pappenheimer, 1950; Schloerb, 1950). It is conceivable that adrenaline accelerates this decrease and thus accelerates the extru- sion of the labelled ions from the vascular bed. The rate of extrusion may be determined by the rate of blood flow which is accelerated by small doses of adrenaline. The fact that adrenaline influences markedly the rate of passage of intravenously injected ^^P as phosphate or ^^Fe circulating as ^-globulin into the extravascular space is not necessarily to be interpreted as due to a change produced in the permeability of the capillary wall. Phosphate which passes from the vascular bed into the interspaces may repeatedly return into the former and escape again. If. however, it took its way from the interspaces into the tissue cells,. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Hevesy, Georg von, 1885-1966. New York, Pergamon Press
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