. Endocrinology. on of these various preparations by intravenous injectionsthe atrophy could be prevented, minimized, or, if possible,hypertrophy could be obtained. At the same time, the breastswere also observed as well as the thyroid, hypophysis and adre-nals, to determine if the administration of these preparations hada definite effect on any of them. Controls were made by subject-ing animals to the same operative procedures, but withoutadministering the drugs. 44 VALUE OF OVARIAN EXTRACTS In the beginning we used 1 ce. of the substance for dailyinjection, but as the animals died after four
. Endocrinology. on of these various preparations by intravenous injectionsthe atrophy could be prevented, minimized, or, if possible,hypertrophy could be obtained. At the same time, the breastswere also observed as well as the thyroid, hypophysis and adre-nals, to determine if the administration of these preparations hada definite effect on any of them. Controls were made by subject-ing animals to the same operative procedures, but withoutadministering the drugs. 44 VALUE OF OVARIAN EXTRACTS In the beginning we used 1 ce. of the substance for dailyinjection, but as the animals died after four or five injections,it was decided to increase the time interval between injections,so that 1 cc. was given every third day, beginning from five toseven days after operation. The castrations w^ere performed in a very simple animals were anaesthetized, the abdomen shaved and ster-ilized with iodine. The ovaries and a small portion of the tubeswere removed without interfering with the blood supply to the. Tie of operation, uterus. At the same time a small segment of the uterus near thehorn was removed as a control and one breast also. Before oper-ation the animals were weighed, and when they had recoveredfrom the operation after a period usually of 48 hours, they wereput on the same food as before operation. Fifty-two animals were used. Several died 24 hours afteroperation of pneumonia and shock. Several died 4-6 days afteroperation from the effects probably of the daily injections GEIST AND HARRIS ^^^^^V/j^v^^: - 1^ ft ??-•_jti ?^ ^ 1^^ Fig. 6. Uterus at time of operation. started 24 hours after operation; some were preguant and nn-suited, leaving 38 animals that could be utilized. Of these 38, 5 received Hynson, Westcott & Dunning CorpusLuteum; 4 received Ilj-nson, Westcott & Dunning Ovarian Sub-stance; 5 received Hynson, Westcott & Dunning Ovarian Resi-due ; 5 received Parke, Davis & Co. Corpus Luteum: 5 received 46 VALUE OF OVARIAN EXTRACTS Parke, Davis &
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Keywords: ., bookcentury1900, bookdecade1910, booksubjectendocrinology, bookye
