. Ciba Foundation Symposium on Transplantation. Transplantation of organs, tissues, etc. 372 PAUL S. RUSSELL A series of 41 newborn C57BL/6 animals was then treated with three injections of 0-37 (or a total of about 2 [jLg. per 17,400,000 DBA CELLS G. 10 2 -. ^methotrexate s/c days If3 bt 5 Untreated Control }0. 75 mg/kg metho- trexate s/c day I 0 20 Days of Age 30 Fig. 15. Individual weight-gain records of a litter of 7 newborn C57BL/6 niice all of which received 17 milHon DBA/1 spleen cells on the first day of hfe. The control died promptly of runt disease. Single injection
. Ciba Foundation Symposium on Transplantation. Transplantation of organs, tissues, etc. 372 PAUL S. RUSSELL A series of 41 newborn C57BL/6 animals was then treated with three injections of 0-37 (or a total of about 2 [jLg. per 17,400,000 DBA CELLS G. 10 2 -. ^methotrexate s/c days If3 bt 5 Untreated Control }0. 75 mg/kg metho- trexate s/c day I 0 20 Days of Age 30 Fig. 15. Individual weight-gain records of a litter of 7 newborn C57BL/6 niice all of which received 17 milHon DBA/1 spleen cells on the first day of hfe. The control died promptly of runt disease. Single injections of amethopterin (methotrexate) (0-75 ) were ineffective in checking the onset of runt disease. Three injections of amethopterin (0-37 ) given on the first, third and fifth days of Hfe allowed four animals to develop at a normal rate. mouse) over the first five days of life following neonatal injections of approximately 15 million DBA/i spleen cells. As indicated in Table I, 59 per cent of these animals survived. Those wliich died tended to do so later than untreated runts. Although many. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Ciba Foundation Symposium on Transplantation (1961 : London, England); Wolstenholme, G. E. W. (Gordon Ethelbert Ward); Cameron, Margaret P. Boston, Little, Brown
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