. Biological transport. Biological transport; Biological Transport. Figure 30 Schematic representation of the hypothetical action of the antidiuretic hormone. Through electrostatic attractions or hydrogen bonding, the hormone is aligned at the receptor site. A thiol-disulfide exchange reaction follows. This triggers a chain reaction of sulfhydryl- disulfide reactions, which brings about conformational changes in the protein components of the diffusion barrier to permit increased flux of water and certain solutes. The hormone-receptor disulfide bond is ultimately cleaved enzymatically to restor
. Biological transport. Biological transport; Biological Transport. Figure 30 Schematic representation of the hypothetical action of the antidiuretic hormone. Through electrostatic attractions or hydrogen bonding, the hormone is aligned at the receptor site. A thiol-disulfide exchange reaction follows. This triggers a chain reaction of sulfhydryl- disulfide reactions, which brings about conformational changes in the protein components of the diffusion barrier to permit increased flux of water and certain solutes. The hormone-receptor disulfide bond is ultimately cleaved enzymatically to restore the membrane to its original state. \_From Fong, C. T. O., et al. (1960), Proc. Natl. Acad. Sci. , 46, 1273; with permission.'] modify migration through the mucosal surface of the cells undoubt- edly has implications for the mode of action. An entirely different proposal as to the mode of action of vaso- pressin has been made by Orloff and associates (1962). These au- thors point out that, under suitable conditions of injection, the hor- mone can mimic the action of ACTH in causing hydrocortisone re- lease from the adrenal cortex and can mimic the action of glucagon in causing glucose release from the liver (Hilton et al., 1959; Bergen et al., 1960). Orloff and his associates suggest that both actions are intermediated by adenosine-3',5' cyclic phosphate. This substance, they suggest, may be frequently involved in actions on membranes. The following scheme is proposed: vasopressin ATP cyclic 3',5'-AMP i i i i i i â¢*â permeability change 98 theophylline -> 5'-AMP. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Christensen, Halvor N. New York, W. A. Benjamin
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