. Ciba Foundation symposium on ionizing radiations and cell metabolism. Radiation -- Physiological effect; Cell metabolism; Radiation -- effects; Radioactivity. Nucleic Acids and Nucleoproteins 61 decrease in particle size, but the relation between it and molecular weight changes is not a simple 2 DOSEXlO"S Fig. 1. Effect of 15 mcv electrons on solid and aqueous DNA. (Measurements by R. H. Pain on materials irradiated by Prof. J. Rotblat.) Chemical changes can also be observed in aqueous solutions although large doses of radiation are required to produce easily measured effects. Amo
. Ciba Foundation symposium on ionizing radiations and cell metabolism. Radiation -- Physiological effect; Cell metabolism; Radiation -- effects; Radioactivity. Nucleic Acids and Nucleoproteins 61 decrease in particle size, but the relation between it and molecular weight changes is not a simple 2 DOSEXlO"S Fig. 1. Effect of 15 mcv electrons on solid and aqueous DNA. (Measurements by R. H. Pain on materials irradiated by Prof. J. Rotblat.) Chemical changes can also be observed in aqueous solutions although large doses of radiation are required to produce easily measured effects. Among the reactions which have H2O / (OH PO4/ ^ â 'H)© ? 'N. OH O, 'C- â¢'CH2-CH ChJKI-C .' N N-C OH \_ / ; ;\' / ^tJ® '"^^^ 'l^H,-'H) Fig. 2. Some chemical effects of radicals on DNA in aqueous solution. been observed (Fig. 2) are (1) deamination of the bases; (2) dehydroxylation; (3) fission of the sugar-base linkage and in some cases breakage of the pyrimidine ring; (4) oxidation of the sugar moiety and (5) breakage of the nucleotide chains. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Ciba Foundation; Wolstenholme, G. E. W. (Gordon Ethelbert Ward); O'Connor, Cecilia M. (Cecilia Mary), 1927-. Boston, Little, Brown
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