. Biological transport. Biological transport; Biological Transport. BIOLOGICAL TRANSPORT in a sequence, not only can metabolism be the cause of transport, but also transport can be the cause of metabolism. Thus, we might be inclined to recognize that transport and metabolism, as usually understood by biochemists, may be conceived advanta- geously as different aspects of one and the same process of vec- torial metabolism. In this hypothesis (Figure 27) the process of oxidative phos- phorylation is seen as a transport, which may be linked to electron transport but which, presumably, may equally
. Biological transport. Biological transport; Biological Transport. BIOLOGICAL TRANSPORT in a sequence, not only can metabolism be the cause of transport, but also transport can be the cause of metabolism. Thus, we might be inclined to recognize that transport and metabolism, as usually understood by biochemists, may be conceived advanta- geously as different aspects of one and the same process of vec- torial metabolism. In this hypothesis (Figure 27) the process of oxidative phos- phorylation is seen as a transport, which may be linked to electron transport but which, presumably, may equally well be linked to a specific molecular transport, functioning instead as an ATP-splitting system. Mitchell's hypothesis offers us a third possibility, beyond those presented in the second and third paragraphs of this chapter, for interpreting flux associations such as those seen between amino acids and the alkali metal ions. Uphill transports may well not be p'aced in series, , with alkali metal transport driving amino acid trans- port; but in parallel, with many or all uphill transports driven by the response of membrane structure to ATP cleavage. The mainte- 2H20^. 2(ADP + P) 2ATP Figure 27 Mitchell's scheme for linkage of electron-transport sys- tem to oxidative phosphorylation, the latter produced by a reversible ATPase system. See text for discussion. {From Mitchell, P. (1961), Na- ture, 191, 144; with permission^ 86. Please note that these images are extracted from scanned page images that may have been digitally enhanced for readability - coloration and appearance of these illustrations may not perfectly resemble the original Christensen, Halvor N. New York, W. A. Benjamin
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