. Pathogenic microörganisms; a practical manual for students, physicians, and health officers . part of the same, so that it cannot again be abstracted from the cell bysolvent agents. According to Ehrlichs theory the first requirement forevery substance against which we can obtain a specific serum must be itspower to enter into such a combination with one or more types of cellsin the living animal. The substance must possess a definite chemicalaffinity for certa,in parts of the organism. Hence, in each substanceagainst whjch we can specifically immunize, EhrUch assumes a groupof atoms which e
. Pathogenic microörganisms; a practical manual for students, physicians, and health officers . part of the same, so that it cannot again be abstracted from the cell bysolvent agents. According to Ehrlichs theory the first requirement forevery substance against which we can obtain a specific serum must be itspower to enter into such a combination with one or more types of cellsin the living animal. The substance must possess a definite chemicalaffinity for certa,in parts of the organism. Hence, in each substanceagainst whjch we can specifically immunize, EhrUch assumes a groupof atoms which effects the specific binding to certain cells, the haptophoregroup (Fig. 67, B). Corresponding to this is a group in the cell of theliving organism, the receptor group, with which the haptophore groupcombines. The haptophore group is distinct from that part of thesubstance which exerts the physiological or pathological effect in toxins, ANTITOXIN 169 for example, from the group which is the carrier of the poisonous action,the so-called toxophore group (^), or in ferments, from the group which. Fig. 67.—Graphic representation of receptors of the first and third orders and of com-plement as conceived by Ehrlich: A, toxophorous group of toxin; B, haptophorous group;C, complement; D, intermediary or immune body; E, foreign cell receptor; F, part of cell. —t M Fig. 68.—Receptors of the secondorder. Here e represents the hap-tophore group, and d the zymo-phore group of the receptor, /being the food molecule with whichthis receptor combines. Such re-ceptors are possessed by agglu-tinins and precipitins. It is to benoted that the zymophore groupis an integral part of the receptor.
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