Sajous's analytical cyclopædia of practical medicine . such as the knee,wrist, and elbow, there have been ob-served enlargement and painful crack-ling, recalling somewhat the phenom-ena noted in mild arthropathies. The circulatory system presents aninteresting group of alterations. \ari-cose veins are said to be frequent, andthe heart is often hypertrophied. [hi 1895 Huchard pointed out the existenceof more or less marked cardiovascular dis-turbances. His pupil, J. B. Fournier (Thesede Paris, 1896), having collected 25 cases,including 12 with autopsy, was led to distin-guish two varieties of c
Sajous's analytical cyclopædia of practical medicine . such as the knee,wrist, and elbow, there have been ob-served enlargement and painful crack-ling, recalling somewhat the phenom-ena noted in mild arthropathies. The circulatory system presents aninteresting group of alterations. \ari-cose veins are said to be frequent, andthe heart is often hypertrophied. [hi 1895 Huchard pointed out the existenceof more or less marked cardiovascular dis-turbances. His pupil, J. B. Fournier (Thesede Paris, 1896), having collected 25 cases,including 12 with autopsy, was led to distin-guish two varieties of cardiac hypertrophy,the one, slight and without degeneration ofthe muscular fibers; the other, accompaniedby sclerosis and atrophy of the contractileelements. Launois and Cesbron.] Symptomatically these changes in thecardiac tissues find their expression inpalpitations, arrhythmia, and dyspnea,and may result finally in asystole. Syn-copal attacks are said to be not imcom-mon. Spinal deformities, when marked,may result in dilatation of the Acromegaly in the Aged—Strabismus. (P. E. Laimois.) ACROMEGALY (LAUNOIS AND CESBRON). 277 H}^pertrophy of the lymphatic vesselsand glands has also been reported. Seusatioi, on the whole, does not ap-pear to be affected. Unusual sensitive-ness to cold is, however, present to acertain extent. The various deformities that wehave described arise and progress, as arule, without giving rise to pain. Insome instances, however, their develop-ment is accompanied by more or lesssevere painful crises, sometimes re-ferred to the viscera, at other times tothe limbs. While sometimes taking theform of a simple myalgia, they may also striking component of the syndrome re-sulting from tumors of the hypophysis,and it is because it has drawn our atten-tion to the hypophysis that the syn-drome due to hypophyseal growths hasbrought forth such a wealth of litera-ture as to make it at present, perhaps,the most abundantly discussed of thesyndrome cause
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