. Adventures in radioisotope research;. Radioactive tracers; Radiobiology. CANCER ANAEMIA 601 The question of whether the curtaihiicnt of the life-time of erythrocytes is attributable to an extracorpuscular effect or to their abnormal syn- thesis can easily be decided by the study of animals. The erythrocytes existing in the healthy organism can be labelled with ^H^ and after incorporation, which proceeds for only a few days at a noticeal)le rate^ the organism is inoculated with cancer cells. If the inoculation with cancer cells affects the life-time of the labelled erythrocytes, it is then ce
. Adventures in radioisotope research;. Radioactive tracers; Radiobiology. CANCER ANAEMIA 601 The question of whether the curtaihiicnt of the life-time of erythrocytes is attributable to an extracorpuscular effect or to their abnormal syn- thesis can easily be decided by the study of animals. The erythrocytes existing in the healthy organism can be labelled with ^H^ and after incorporation, which proceeds for only a few days at a noticeal)le rate^ the organism is inoculated with cancer cells. If the inoculation with cancer cells affects the life-time of the labelled erythrocytes, it is then certain that extracorpuscular agents are playing a part. Ehrenstein Cancer inoculated • Cancer o Control. Fig. 3. Loss of ^*C by the haemin of red corpuscles of control mice and such inoculated with ascites cancer cells 5 days following injection of glycine-i'iC. in our laboratory has injected one hundred mice, each with 1 /uc of glycocoll-2-i^C, killed groups of ten mice at different times, isolated 20 mgm of haemin from the red corpuscles and compared the radioactivi- ties of the haemin samples obtained at various times. With another batch of one hundred mice the procedure was the same, except that these were injected with Ehrlich carcinoma cells 5 days after the beginning of the experiment. As shown in Fig. 3, the life-time of the erythrocytes in the tumorous mice (tumour weight 1 — 3 gm) was lowered to about one-half of the normal value. Because of the rapid disappearance of haemoglobin from the circulatory system of the cancerous animal, it would be expected that they would show a lowered haemoglobin content. This was not the case; the cancerous animals had the same total of 360 mgm haemoglobin content as the controls and there was a marked decrease in the haemoglobin content just before the death of the animals. This result can be explained only by a compensation of the more rapid decay of the blood corpuscles in the neoplastic organism by a more rapid formation of eryt
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