. Endocrinology. hoidism of this animal Avas not caused by the fact that thequantity of testicular substance was too small, is shown byour numerous experiments on guinea pigs. In these animalsextraordinarily small testicular fragments, representing onlyabout 1 per cent of the weight of two normal testicles, weresufficient for the full development of the somatic sexual charac-ters (5). The eunuchoidism in this experiment must have beencaused by the underdevelopment of the testicular fragment as LIPSCHUTZ 3 shown by microscopical examination. The seminiferous tubuleswere somewhat further develop
. Endocrinology. hoidism of this animal Avas not caused by the fact that thequantity of testicular substance was too small, is shown byour numerous experiments on guinea pigs. In these animalsextraordinarily small testicular fragments, representing onlyabout 1 per cent of the weight of two normal testicles, weresufficient for the full development of the somatic sexual charac-ters (5). The eunuchoidism in this experiment must have beencaused by the underdevelopment of the testicular fragment as LIPSCHUTZ 3 shown by microscopical examination. The seminiferous tubuleswere somewhat further developed than in an animal of about twomonths, the diameter being greatly enlarged, and the quantityof cells, likely cells of Sertoli, being increased. Spermatogoniawere present. Some tubules were filled with desquamated cells;it seems that these were cells of Sertoli surrounding spermato-gonia. The intertubular tissue was richly developed, but consistedchiefly of common connective tissue. As far as cells. Fig. 2. Section through testicle of a rabbit 6V2 months old. seniicastratedat an age of 6 weeks. The animal had the penis of a castrate. The inter-tubular tissue is rich in connective fibres and spindle shaped nuclei. Interstitialcells with a small area of protoplasm and with a smaller nucleus. Seminaltubules in full spermatogenesis inot drawn) and of the same diameter as in Fig. and stain, as Fig. 1. were recognizable they had the infantile form, i. e., a smallernucleus and a small quantity of protoplasm. In general it wasdifficult to distinguish them from common connective tissuecells. This observation shows that in the presence of spermato-gonia and of cells of Sertoli the internal secretion of the testicleis not possible when the interstitial cells are underdeveloped. An objection can be made against our : It may bethat the animal in the experiment mentioned remained eunuchoid, 4 8EAT OF ENDOCRINE FUNCTION OF TESTICLE not because the interst
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